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These findings should be interpreted with caution because this was a very short-term investigation (only 6 weeks), and the authors of that research had connections with nicotine pouch manufacturers [53]

Other factors are related to lifestyle choices such as smoking

When mitochondrial damage exceeds the clearance capacity of the quality control mechanisms, a disordered state that fails to effectively deal with mitochondrial dysfunction ensues, further exacerbating functional abnormalities and creating a vicious cycle that may contribute to COPD progression

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Edith Mitchell, a medical oncologist at the Sidney Kimmel Cancer Center in Philadelphia, said that in addition to promoting healthy habits such as quitting smoking and exercising, studies should also focus on genetics, biology, and social and environmental factors